Compound Formula Rehmannia alleviates levodopa-induced dyskinesia in Parkinson's disease
Identifieur interne : 000067 ( Main/Exploration ); précédent : 000066; suivant : 000068Compound Formula Rehmannia alleviates levodopa-induced dyskinesia in Parkinson's disease
Auteurs : Long Teng [République populaire de Chine] ; Fang Hong [République populaire de Chine] ; Chenguang Zhang [République populaire de Chine] ; Jiancheng He [République populaire de Chine] ; Haiying Wang [République populaire de Chine]Source :
- Neural Regeneration Research [ 1673-5374 ] ; 2014.
Abstract
Compound Formula Rehmannia has been shown to be clinically effective in treating Parkinson's disease and levodopa-induced dyskinesia; however, the mechanisms remain unclear. In this study, we established a model of Parkinson's disease dyskinesia in rats, and treated these animals with Compound Formula Rehmannia. Compound Formula Rehmannia inhibited the increase in mRNA expression of N-methyl-D-aspartate receptor subunits 1 and 2 and excitatory amino acid neurotransmitter genes, and it inhibited the reduction in expression of γ-aminobutyric acid receptor B1, an inhibitory amino acid neurotransmitter gene, in the corpus striatum. In addition, Compound Formula Rehmannia alleviated dyskinesia symptoms in the Parkinson's disease rats. These experimental findings indicate that Compound Formula Rehmannia alleviates levodopa-induced dyskinesia in Parkinson's disease by modulating neurotransmitter signaling in the corpus striatum.
Url:
DOI: 10.4103/1673-5374.128246
PubMed: 25206828
PubMed Central: 4146199
Affiliations:
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Teng</name><affiliation wicri:level="1"><nlm:aff id="aff1">Shanghai University of Traditional Chinese Medicine, Shanghai, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai University of Traditional Chinese Medicine, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Hong, Fang" sort="Hong, Fang" uniqKey="Hong F" first="Fang" last="Hong">Fang Hong</name><affiliation wicri:level="1"><nlm:aff id="aff1">Shanghai University of Traditional Chinese Medicine, Shanghai, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai University of Traditional Chinese Medicine, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Chenguang" sort="Zhang, Chenguang" uniqKey="Zhang C" first="Chenguang" last="Zhang">Chenguang Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff1">Shanghai University of Traditional Chinese Medicine, Shanghai, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai University of Traditional Chinese Medicine, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="He, Jiancheng" sort="He, Jiancheng" uniqKey="He J" first="Jiancheng" last="He">Jiancheng He</name><affiliation wicri:level="1"><nlm:aff id="aff1">Shanghai University of Traditional Chinese Medicine, Shanghai, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai University of Traditional Chinese Medicine, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Haiying" sort="Wang, Haiying" uniqKey="Wang H" first="Haiying" last="Wang">Haiying Wang</name><affiliation wicri:level="1"><nlm:aff id="aff1">Shanghai University of Traditional Chinese Medicine, Shanghai, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai University of Traditional Chinese Medicine, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author></analytic><series><title level="j">Neural Regeneration Research</title><idno type="ISSN">1673-5374</idno><idno type="eISSN">1876-7958</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Compound Formula Rehmannia has been shown to be clinically effective in treating Parkinson's disease and levodopa-induced dyskinesia; however, the mechanisms remain unclear. In this study, we established a model of Parkinson's disease dyskinesia in rats, and treated these animals with Compound Formula Rehmannia. Compound Formula Rehmannia inhibited the increase in mRNA expression of N-methyl-D-aspartate receptor subunits 1 and 2 and excitatory amino acid neurotransmitter genes, and it inhibited the reduction in expression of γ-aminobutyric acid receptor B1, an inhibitory amino acid neurotransmitter gene, in the corpus striatum. In addition, Compound Formula Rehmannia alleviated dyskinesia symptoms in the Parkinson's disease rats. These experimental findings indicate that Compound Formula Rehmannia alleviates levodopa-induced dyskinesia in Parkinson's disease by modulating neurotransmitter signaling in the corpus striatum.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Pezzoli, G" uniqKey="Pezzoli G">G Pezzoli</name></author><author><name sortKey="Zini, M" uniqKey="Zini M">M Zini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sethi, Kd" uniqKey="Sethi K">KD Sethi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, Jc" uniqKey="He J">JC He</name></author><author><name sortKey="Yuan, Cx" uniqKey="Yuan C">CX Yuan</name></author><author><name sortKey="Wei, Hc" uniqKey="Wei H">HC Wei</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sheng, Hm" uniqKey="Sheng H">HM Sheng</name></author><author><name sortKey="He, Jc" uniqKey="He J">JC 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sort="He, Jiancheng" uniqKey="He J" first="Jiancheng" last="He">Jiancheng He</name><name sortKey="Hong, Fang" sort="Hong, Fang" uniqKey="Hong F" first="Fang" last="Hong">Fang Hong</name><name sortKey="Wang, Haiying" sort="Wang, Haiying" uniqKey="Wang H" first="Haiying" last="Wang">Haiying Wang</name><name sortKey="Zhang, Chenguang" sort="Zhang, Chenguang" uniqKey="Zhang C" first="Chenguang" last="Zhang">Chenguang Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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